Abstract
Descriptive clinical data help to reveal factors that may provoke Zika virus (ZIKV) neuropathology. The case of a 24-year-old female with a ZIKV-associated severe acute neurological disorder was studied. The levels of ZIKV in the cerebrospinal fluid (CSF) were 50 times higher than the levels in other compartments. An acute anti-flavivirus IgG, together with enhanced TNF-alpha levels, may have contributed to ZIKV invasion in the CSF, whereas the unbiased genome sequencing [obtained by next-generation sequencing (NGS)] of the CSF revealed that no virus mutations were associated with the anatomic compartments (CSF, serum, saliva and urine).
Keywords:
Brazil; Rio de Janeiro; Zika virus; neurological disease; neurotropism; zika.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibodies, Viral / cerebrospinal fluid*
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Female
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Genome, Viral
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Humans
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Immunoglobulin G / cerebrospinal fluid*
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Neurogenic Inflammation / complications
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Neurogenic Inflammation / diagnosis*
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Neurogenic Inflammation / physiopathology
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Neurogenic Inflammation / virology
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Phylogeny
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Tumor Necrosis Factor-alpha / cerebrospinal fluid*
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Whole Genome Sequencing
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Young Adult
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Zika Virus / classification
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Zika Virus / genetics*
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Zika Virus / isolation & purification
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Zika Virus / pathogenicity
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Zika Virus Infection / complications
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Zika Virus Infection / diagnosis*
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Zika Virus Infection / physiopathology
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Zika Virus Infection / virology
Substances
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Antibodies, Viral
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Immunoglobulin G
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Tumor Necrosis Factor-alpha