[Detection of differentially expressed gene of allergic rhinitis based on RT² profiler PCR array]

Y Peng; X Q Li; Q H Qiu

doi:10.13201/j.issn.1001-1781.2017.11.012

[Detection of differentially expressed gene of allergic rhinitis based on RT² profiler PCR array]

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 Jun 5;31(11):869-872. doi: 10.13201/j.issn.1001-1781.2017.11.012.

[Article in Chinese]

Authors

Y Peng¹, X Q Li², Q H Qiu²

Affiliations

¹ Department of Graduate School, Southern Medical University, Guangzhou, 510515, China.
² Department of Otolaryngology Head and Neck Surgery, Guangdong General Hospital and Guangdong Academy of Medical Sciences.

PMID: 29775004
DOI: 10.13201/j.issn.1001-1781.2017.11.012

Abstract

Objective:The aim of this study is to detect differentially expressed gene of allergic rhinitis (AR) based on RT² profiler PCR array. Method:The real-time PCR array containing 84 genes were used to compare inferior turbinate samples obtained from AR patients (n=8) and healthy individuals (n=8). Result:The results showed that 67 genes were down regulated and 17 genes were up regulated in AR inferior turbinate after analysis of 84 genes related to allergy and asthma. STAT6 and BCL6 were recognized as differentially expressed genes. Conclusion:The real-time PCR array can provide new insight into the pathophysiological processes involved in AR.

Keywords: real-time PCR array; rhinitis, allergic.

MeSH terms

Asthma / genetics*
Case-Control Studies
Gene Expression Profiling*
Humans
Real-Time Polymerase Chain Reaction*
Rhinitis, Allergic / genetics*
Turbinates