Abstract
GALT contains Tcs cells which protect IgA responses under conditions of oral tolerance. Oral immunization of erythrocyte antigen induces antigen-specific Tcs cells in Peyer's patches which predominantly support IgA responses with minor IgM and IgG responses upon adoptive transfer to tolerized mice. On the other hand, systemically-primed mice possess Tcs cells which convert oral tolerance to only IgM and IgG responses. In general, effector Tcs cells which abrogate antigen-specific oral tolerance are Lyt-1+, Lyt-2-, L3T4-, I-J+ and V. villosa-adherent. Interestingly, these Tcs cells express T3 molecules which suggest the expression of a TCR which may account for their antigen specificity.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Administration, Oral
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Animals
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Antibody Formation*
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Antigens / administration & dosage
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Antigens, Differentiation, T-Lymphocyte / analysis
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Antigens, Ly / analysis
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Immune Tolerance
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Immunoglobulin A / biosynthesis*
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Immunoglobulin Isotypes / biosynthesis*
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Intestines / cytology
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Intestines / immunology*
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Mice
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Mucous Membrane / immunology
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Peyer's Patches / immunology
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T-Lymphocytes / classification
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T-Lymphocytes / immunology*
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T-Lymphocytes, Helper-Inducer / immunology*
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T-Lymphocytes, Regulatory / immunology*
Substances
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Antigens
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Antigens, Differentiation, T-Lymphocyte
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Antigens, Ly
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Immunoglobulin A
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Immunoglobulin Isotypes