Abstract
The mechanistic target of rapamycin complex 1 (mTORC1) has been reported to be necessary for metabotropic glutamate receptor-mediated long-term depression (mGluR-LTD). Here we found that mTORC1-deficient mice exhibit normal hippocampal mGluR-LTD and associated behaviors. Moreover, rapamycin blocks mGluR-LTD in mTORC1-deficient mice. However, both rapamycin and mGluR activation regulate mTOR complex 2 (mTORC2) activity, and mTORC2-deficient mice show impaired mGluR-LTD and associated behaviors. Thus, mTORC2 is a major regulator of mGluR-LTD.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Behavior, Animal / physiology
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Electrophysiological Phenomena / physiology
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Female
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Hippocampus / physiology*
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Learning / physiology
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Long-Term Synaptic Depression / genetics*
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Long-Term Synaptic Depression / physiology*
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Male
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Mechanistic Target of Rapamycin Complex 1 / genetics*
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Mechanistic Target of Rapamycin Complex 1 / physiology*
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Mechanistic Target of Rapamycin Complex 2 / genetics*
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Mechanistic Target of Rapamycin Complex 2 / physiology*
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Memory / physiology
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Receptors, Metabotropic Glutamate / physiology*
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Recognition, Psychology
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Regulatory-Associated Protein of mTOR / genetics
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Regulatory-Associated Protein of mTOR / physiology
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Sirolimus / pharmacology
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Space Perception / physiology
Substances
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Receptors, Metabotropic Glutamate
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Regulatory-Associated Protein of mTOR
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Rptor protein, mouse
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Mechanistic Target of Rapamycin Complex 1
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Mechanistic Target of Rapamycin Complex 2
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Sirolimus