Abstract
Over the past decades, a number of novel compounds, which are produced in the marine environment, have been found to exhibit the anticancer effects. This review focuses on molecular targets of marine-derived anticancer candidates in clinical and preclinical studies. They are kinases, transcription factors, histone deacetylase, the ubiquitin-proteasome system, and so on. Specific emphasis of this review paper is to provide information on the optimization of new target compounds for future research and development of anticancer drugs, based on the identification of structures of these target molecules and parallel compounds.
Keywords:
anticancer compounds; marine sources; molecular targets.
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Antineoplastic Agents / therapeutic use
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Aquatic Organisms / chemistry*
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Drug Design*
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Drug Discovery*
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Drug Resistance, Multiple
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Drug Resistance, Neoplasm
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Drugs, Investigational / chemistry
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Drugs, Investigational / isolation & purification*
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Drugs, Investigational / pharmacology
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Drugs, Investigational / therapeutic use
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology
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Enzyme Inhibitors / therapeutic use
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Epigenesis, Genetic / drug effects
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Gene Expression Regulation, Neoplastic / drug effects
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Humans
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Molecular Structure
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Molecular Targeted Therapy
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Neoplasm Proteins / antagonists & inhibitors
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Neoplasm Proteins / genetics
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Neoplasm Proteins / metabolism
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Neoplasms / drug therapy
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Neoplasms / enzymology
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Neoplasms / metabolism
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Proteasome Endopeptidase Complex / drug effects
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Proteasome Endopeptidase Complex / metabolism
Substances
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Antineoplastic Agents
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Drugs, Investigational
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Enzyme Inhibitors
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Neoplasm Proteins
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Proteasome Endopeptidase Complex