Polyspecific Intravenous Immunoglobulin in Clindamycin-treated Patients With Streptococcal Toxic Shock Syndrome: A Systematic Review and Meta-analysis

Clin Infect Dis. 2018 Oct 15;67(9):1434-1436. doi: 10.1093/cid/ciy401.

Abstract

We evaluated the effect of intravenous immunoglobulin (IVIG) on mortality in clindamycin-treated streptococcal toxic shock syndrome using a meta-analysis. In association with IVIG, mortality fell from 33.7% to 15.7% with remarkable consistency across the single randomized and four nonrandomized studies.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Systematic Review

MeSH terms

  • Clindamycin / therapeutic use*
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use*
  • Shock, Septic / drug therapy*
  • Shock, Septic / mortality
  • Streptococcal Infections / drug therapy*
  • Streptococcal Infections / mortality
  • Streptococcus pyogenes
  • Treatment Outcome

Substances

  • Immunoglobulins, Intravenous
  • Clindamycin