[Expression and clinical significance of HIF-1α in laryngeal carcinoma]

Objective:To investigate the expression and clinical significance of HIF-1α in laryngeal carcinoma(LC). Method:Databases including PubMed, EMbase, Web of Science, VIP, CNKI and Wan-Fang Data were searched from 2000.1 to 2015.12, and all relevant references were also retrieved to collect relevant case-control studies. The included studies were screened according to the exclusion criteria. Then the meta-analysis was conducted by RevMan 5.3 software. Result:A total of 5 case-control studies involving 202 LC tissues and 75 normal laryngeal tissues were included. The results of the meta-analyses showed that, as for the positive rate of HIF-1α expression, it was higher in LC tissues than that in normal esophageal tissues ［OR=22.4，95%CI (9.79，51.25)，P<0.01］, in LC tissues with lymph node metastasis than in that without lymph node metastasis ［OR=7.10，95%CI (3.10, 16.30), P<0.01］, in moderate and low differentiated LC tissues than those in high differentiated LC tissues［OR=4.40, 95%CI (2.28, 8.49), P<0.01］.The expression of HIF-1α in clinical stage Ⅲ-Ⅳ was significantly higher than that in clinical stage Ⅰ-Ⅱ［OR=5.89, 95%CI (2.44, 14.24), P<0.01］. Conclusion:The present limited evidence shows that the HIF-1α expression is associated with LC, lymph node metastasis, degree of cell differentiation and clinical stage of LC, indicating that LC may take a role in the whole course of carcinogenesis of LC. Further well-designed and high quality case-control studies are needed to prove the results.