[Desmocollin-1 significant correlated with the tumorigenesis and prognosis of HNSCC]

F Kou; F Li; L Wang; D Yu; C Chen; S M Chen; B K Xiao; Z Z Tao

doi:10.13201/j.issn.1001-1781.2016.10.001

[Desmocollin-1 significant correlated with the tumorigenesis and prognosis of HNSCC]

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 May 20;30(10):763-766. doi: 10.13201/j.issn.1001-1781.2016.10.001.

[Article in Chinese]

Authors

F Kou¹, F Li¹, L Wang¹, D Yu¹, C Chen¹, S M Chen¹, B K Xiao¹, Z Z Tao¹

Affiliation

¹ Department of OtolaryngologyHead and Neck Surgery, Renmin Hospital of Wuhan University,Research Institute of Otolaryngology-Head and Neck Surgery, Wuhan, 430060,China.

PMID: 29798048
DOI: 10.13201/j.issn.1001-1781.2016.10.001

Abstract

Objective:To explore the correlation between the expression of desmocollin1and the tumorigenesis and prognosis of HNSCC.Method:Five datasets of HNSCC from the GEO were analyzed. A tumor tissue microassay was chosen for further test. The expression of DSC1 of TMA was detected by immunohistochemical staining. Result:The expression of DSC1 was significantly increased in HNSCC. Meanwhile, the expression of DSC1 was much higher in poor-differentiated tumor than the welldifferentiated tumor in HNSCC. What's more, the HNSCC patients with lower expression of DSC1 had better outcomes. Conclusion:The results were according with the results of statistical analysis with the bioinformatics data from GEO, indicating that DSC1 significant correlated with the tumorigenesis and prognosis of HNSCC.

Keywords: HNSCC; NCBI database; desmocollin-1; prognosis; tissue microassay.

MeSH terms

Carcinogenesis
Carcinoma, Squamous Cell / diagnosis
Carcinoma, Squamous Cell / metabolism*
Desmocollins / metabolism*
Gene Expression Regulation, Neoplastic*
Head and Neck Neoplasms / diagnosis
Head and Neck Neoplasms / metabolism*
Humans
Prognosis

Substances

DSC1 protein, human
Desmocollins