[The expression and clinical significance of survivin in salivary gland adenoid cystic carcinoma: a Meta analysis]

Objective:This Meta-analysis was performed to explore the association between survivin expression and clinical pathological features of salivary gland adenoid cystic carcinoma (SACC). Method:Literature was searched in some databases such as PubMed, Embase, Cochrane Library, web of science, OVID, Springerlink, CNKI, CBM, Wanfang and CQVIP. The pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated to determine the correlation between survivin expression and SACC using a fixed or random effects model according to heterogeneity. Result:A total of ten studies with 367 SACC patients and 124 normal control subjects were included in this Meta-analysis. The results showed that survivin was overexpressed in SACC tissues (OR=38.26, 95% CI: 17.37-84.29, P<0.01). It also revealed significant correlations between survivin expression and pathological types (OR=0.3, 95% CI: 0.17-0.55, P<0.01), advanced tumor clinical stages (OR=0.23, 95% CI: 0.13-0.42, P<0.01) and lymph node metastasis (OR=3.7, 95% CI: 1.82-7.56, P<0.01). Conclusion:The current study demonstrated that survivin expression may be associated with the clinical pathological features of SACC. However, due to the influence of the quantity and quality of the included literature, additional high quality of studies with larger sample sizes are needed to confirm our findings.