Abstract
Boronic acid liposomes enable triggered content release and cell delivery driven by carbohydrate binding. Dye release assays using hydrophilic and hydrophobic fluorophores validate dose-dependent release upon carbohydrate treatment. Microscopy results indicate dramatic enhancements in cell delivery, showcasing the prospects of boronic acid lipids for drug delivery.
MeSH terms
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Boronic Acids / chemical synthesis
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Boronic Acids / chemistry*
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Boronic Acids / metabolism
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Boronic Acids / toxicity
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Cell Line, Tumor
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Diglycerides / chemical synthesis
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Diglycerides / chemistry*
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Diglycerides / metabolism
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Diglycerides / toxicity
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Drug Carriers / chemical synthesis
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Drug Carriers / chemistry*
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Drug Carriers / metabolism
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Drug Carriers / toxicity
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Drug Liberation
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Fluorescent Dyes / chemistry
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Heparin / chemistry*
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Humans
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Oxazines / chemistry
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Pinocytosis / drug effects
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Rhodamines / chemistry
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Unilamellar Liposomes / chemical synthesis
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Unilamellar Liposomes / chemistry*
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Unilamellar Liposomes / metabolism
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Unilamellar Liposomes / toxicity
Substances
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Boronic Acids
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Diglycerides
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Drug Carriers
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Fluorescent Dyes
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Oxazines
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Rhodamines
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Unilamellar Liposomes
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lissamine rhodamine B
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Heparin
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nile red