Identification of enzymatic activities which process protein bound mono(ADP-ribose)

Biochem Biophys Res Commun. 1985 Jan 16;126(1):136-42. doi: 10.1016/0006-291x(85)90582-0.

Abstract

Enzymatic activities have been identified in extracts of cultured mouse cells which catalyze the removal of intact mono(ADP-ribosyl) residues linked to proteins at arginine. Activities that sequentially remove AMP and ribose 5-phosphate have also been identified. These results suggest that mono(ADP-ribosylation) of proteins is a reversible post translational modification.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenosine Diphosphate Ribose / metabolism*
  • Animals
  • Cell Transformation, Viral
  • Chromatography, Paper
  • Fibroblasts / enzymology*
  • Histones / metabolism
  • Magnesium / pharmacology
  • Magnesium Chloride
  • Mice
  • Nucleoside Diphosphate Sugars / metabolism*
  • Protein Processing, Post-Translational*
  • Simian virus 40

Substances

  • Histones
  • Nucleoside Diphosphate Sugars
  • Magnesium Chloride
  • Adenosine Diphosphate Ribose
  • Magnesium