A "Counter-Enhancer" in Tumor Suppression

Francesco P Marchese; Maite Huarte

doi:10.1016/j.cell.2018.05.023

A "Counter-Enhancer" in Tumor Suppression

Cell. 2018 May 31;173(6):1318-1319. doi: 10.1016/j.cell.2018.05.023. Epub 2018 May 31.

Authors

Francesco P Marchese¹, Maite Huarte²

Affiliations

¹ University of Navarra, Center for Applied Medical Research (CIMA), Pamplona 31008, Spain; Institute of Health Research of Navarra (IdiSNA), Pamplona 31008, Spain.
² University of Navarra, Center for Applied Medical Research (CIMA), Pamplona 31008, Spain; Institute of Health Research of Navarra (IdiSNA), Pamplona 31008, Spain. Electronic address: [email protected].

PMID: 29856950
DOI: 10.1016/j.cell.2018.05.023

Abstract

The role of the noncoding genome in cancer biology is continually expanding. Cho et al. reveal a new and unexpected mechanism for the regulation of MYC expression mediated by the promoter sequence of its neighbor gene PVT1. This DNA element acts as a promoter-enhancer competitor and a candidate tumor suppressor.

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MeSH terms

Cell Line, Tumor
DNA, Neoplasm
Promoter Regions, Genetic*
RNA, Long Noncoding*

Substances

DNA, Neoplasm
RNA, Long Noncoding