The relationship between Vitamin D status and exacerbation in COPD patients- a literature review

Renata Ferrari; Laura M O Caram; Suzana E Tanni; Irma Godoy; Sergio Alberto Rupp de Paiva

doi:10.1016/j.rmed.2018.04.012

The relationship between Vitamin D status and exacerbation in COPD patients- a literature review

Respir Med. 2018 Jun:139:34-38. doi: 10.1016/j.rmed.2018.04.012. Epub 2018 Apr 23.

Authors

Renata Ferrari¹, Laura M O Caram², Suzana E Tanni³, Irma Godoy⁴, Sergio Alberto Rupp de Paiva⁵

Affiliations

¹ Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu Campus, Department of Internal Medicine, Pneumology Area, São Paulo, Brazil. Electronic address: [email protected].
² Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu Campus, Department of Internal Medicine, Pneumology Area, São Paulo, Brazil. Electronic address: [email protected].
³ Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu, Brazil. Electronic address: [email protected].
⁴ Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu Campus, Department of Internal Medicine, Pneumology Area, São Paulo, Brazil. Electronic address: [email protected].
⁵ Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu Campus, Department of Internal Medicine, Internal Medicine Area, São Paulo, Brazil. Electronic address: [email protected].

PMID: 29857999
DOI: 10.1016/j.rmed.2018.04.012

Abstract

Objective: To investigate the relationship between Vitamin D and exacerbation in COPD patients.

Methods: The PubMed database was searched for articles published from 2012 onwards using search terms related to Vitamin D and exacerbation in COPD patients. Meta-analysis, clinical trials, observational studies, and human studies were included. Non-English articles or articles with full text unavailable were excluded; a total of 15 articles were selected.

Results: The association between exacerbation frequency and Vitamin D levels in observational studies remains controversial, however, meta-analysis revealed a negative association between serum Vitamin D and exacerbation. Also, two clinical trials showed that Vitamin D3 supplementation in COPD patients reduced the risk of moderate and severe exacerbation. Vitamin D binding protein (VDBP) polymorphisms seem to affect patient exacerbation susceptibility.

Conclusions: Few studies in literature have data related to diet, 25-hydroxyVitamin D [25(OH)D] and polymorphism in COPD exacerbation. One clinical trial indicates Vitamin D supplementation plays a role in COPD patients with hypovitaminosis D in preventing exacerbations. Further studies are needed to elucidate the role of Vitamin D in this population and to establish the best marker for Vitamin D, which patient subgroups will benefit, and the best supplement dosage without leading to toxicity.

Keywords: Chronic obstructive pulmonary disease; Exacerbation; Polymorphisms; Supplementation; Vitamin D.

Publication types

Review

MeSH terms

Clinical Trials as Topic
Female
Humans
Male
Meta-Analysis as Topic
Observational Studies as Topic
Polymorphism, Genetic
Pulmonary Disease, Chronic Obstructive / blood*
Pulmonary Disease, Chronic Obstructive / diet therapy
Pulmonary Disease, Chronic Obstructive / genetics
Vitamin D / administration & dosage
Vitamin D / analogs & derivatives*
Vitamin D / blood
Vitamin D Deficiency / complications
Vitamin D-Binding Protein / genetics*

Substances

GC protein, human
Vitamin D-Binding Protein
Vitamin D
25-hydroxyvitamin D