This report describes a case of esophageal intramural pseudodiverticulosis associated with an inflammatory esophageal mass with high 18F-fluorodeoxyglucose (FDG) uptake. A 48-year-old man presented with dysphagia caused by an esophageal stricture. Simultaneous positron emission tomography and magnetic resonance imaging showed an FDG-avid lesion in the lower esophagus. Because of suspected malignancy, the patient underwent subtotal esophagectomy. Histologic examination confirmed the diagnosis of an inflammatory tumor associated with esophageal pseudodiverticulosis. Unlike typical cases, this patient's pseudodiverticula involved both the submucosa and the muscularis propria. This case suggests that esophageal intramural pseudodiverticulosis can manifest with a tumorlike mass that may be FDG positive in response to associated inflammation.
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