Organoid Center Strategies for Accelerating Clinical Translation

Takanori Takebe; James M Wells; Michael A Helmrath; Aaron M Zorn

doi:10.1016/j.stem.2018.05.008

Organoid Center Strategies for Accelerating Clinical Translation

Cell Stem Cell. 2018 Jun 1;22(6):806-809. doi: 10.1016/j.stem.2018.05.008.

Authors

Takanori Takebe¹, James M Wells², Michael A Helmrath³, Aaron M Zorn⁴

Affiliations

¹ Center for Stem Cell and Organoid Medicine (CuSTOM), Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA; Institute of Research, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan; Advanced Medical Research Center, Yokohama City University, 3-9 Fukuura, Kanazawa, Yokohama 236-0004, Japan. Electronic address: [email protected].
² Center for Stem Cell and Organoid Medicine (CuSTOM), Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA.
³ Center for Stem Cell and Organoid Medicine (CuSTOM), Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
⁴ Center for Stem Cell and Organoid Medicine (CuSTOM), Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA. Electronic address: [email protected].

Abstract

The meteoric rise in stem-cell-derived organoid technologies has ushered in a new era of "organoid medicine." Here we discuss how an organoid center can accelerate the translation of laboratory proof-of-principle experiments into clinical practice by developing and utilizing shared platforms for commercial and medical applications.

MeSH terms

Humans
Inflammatory Bowel Diseases / therapy*
Organoids / cytology*
Organoids / metabolism
Stem Cells / cytology*
Stem Cells / metabolism
Translational Research, Biomedical / methods*

Abstract

MeSH terms

Grants and funding