Neuregulin 1 (NRG1) gene expression predicts functional outcomes in individuals at clinical high-risk for psychosis

Vinita Jagannath; Miriam Gerstenberg; Susanne Walitza; Maurizia Franscini; Karsten Heekeren; Wulf Rössler; Anastasia Theodoridou; Edna Grünblatt

doi:10.1016/j.psychres.2018.05.025

Neuregulin 1 (NRG1) gene expression predicts functional outcomes in individuals at clinical high-risk for psychosis

Psychiatry Res. 2018 Aug:266:143-146. doi: 10.1016/j.psychres.2018.05.025. Epub 2018 May 17.

Authors

Vinita Jagannath¹, Miriam Gerstenberg¹, Susanne Walitza², Maurizia Franscini¹, Karsten Heekeren³, Wulf Rössler⁴, Anastasia Theodoridou³, Edna Grünblatt⁵

Affiliations

¹ Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland.
² Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland; The Zurich Program for Sustainable Development of Mental Health Services (ZInEP), University Hospital of Psychiatry Zurich, Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland; Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.
³ The Zurich Program for Sustainable Development of Mental Health Services (ZInEP), University Hospital of Psychiatry Zurich, Zurich, Switzerland; Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland.
⁴ The Zurich Program for Sustainable Development of Mental Health Services (ZInEP), University Hospital of Psychiatry Zurich, Zurich, Switzerland.
⁵ Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland; Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland. Electronic address: [email protected].

PMID: 29864613
DOI: 10.1016/j.psychres.2018.05.025

Abstract

Little is known about valid predictive markers for functional outcomes in an at-risk for psychosis population. In a cohort of 185 individuals (age: 13-35 years) at high risk (HR) and ultra-high risk (UHR), we assessed pan-NRG1 mRNA levels across good functional status (GFS) and poor functional status (PFS) at baseline, and good functional outcome (GFO) and poor functional outcome (PFO) at 12-month follow-up. NRG1 mRNA levels were significantly higher in individuals with PFO than individuals with GFO at 12-month follow-up. Our findings suggest that NRG1 might emerge as a predictive marker for functional outcomes in at-risk for psychosis population.

Keywords: At-risk psychosis; High risk (HR); Ultra-high risk (UHR).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Biomarkers / blood
Cohort Studies
Female
Follow-Up Studies
Gene Expression
Humans
Male
Neuregulin-1 / biosynthesis*
Neuregulin-1 / blood
Neuregulin-1 / genetics*
Predictive Value of Tests
Psychiatric Status Rating Scales
Psychotic Disorders / blood
Psychotic Disorders / genetics*
Psychotic Disorders / metabolism*
Risk Factors
Treatment Outcome
Young Adult

Substances

Biomarkers
NRG1 protein, human
Neuregulin-1