Time Series Integrative Analysis of RNA Sequencing and MicroRNA Expression Data Reveals Key Biologic Wound Healing Pathways in Keloid-Prone Individuals

Alexandros Onoufriadis; Chao-Kai Hsu; Chrysanthi Ainali; Chuin Ying Ung; Ellie Rashidghamat; Hsing-San Yang; Hsin-Yu Huang; Umar Niazi; Christos Tziotzios; Jui-Chu Yang; Rosamond Nuamah; Ming-Jer Tang; Alka Saxena; Emanuele de Rinaldis; John A McGrath

doi:10.1016/j.jid.2018.05.017

Time Series Integrative Analysis of RNA Sequencing and MicroRNA Expression Data Reveals Key Biologic Wound Healing Pathways in Keloid-Prone Individuals

J Invest Dermatol. 2018 Dec;138(12):2690-2693. doi: 10.1016/j.jid.2018.05.017. Epub 2018 Jun 2.

Authors

Affiliations

¹ St John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, London, UK.
² Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; International Center for Wound Repair and Regeneration (iWRR), National Cheng Kung University, Tainan, Taiwan.
³ Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
⁴ Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; School of Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
⁵ Guy's and St Thomas' National Health Service Foundation Trust and King's College London National Institute for Health Research Biomedical Research Centre Translational Bioinformatics Platform, Guy's Hospital, London, UK.
⁶ Human Biobank, Research Centre of Clinical Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.
⁷ Guy's and St Thomas' National Health Service Foundation Trust and King's College London National Institute for Health Research Biomedical Research Centre Genomics Research Platform, Guy's Hospital, London, UK.
⁸ International Center for Wound Repair and Regeneration (iWRR), National Cheng Kung University, Tainan, Taiwan; Department of Physiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
⁹ St John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, London, UK. Electronic address: [email protected].

PMID: 29870686
DOI: 10.1016/j.jid.2018.05.017

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Disease Susceptibility
Female
Humans
Keloid / diagnosis
Keloid / genetics*
MAP Kinase Signaling System
Male
MicroRNAs / genetics*
Middle Aged
Pedigree
Receptors, Notch / genetics
Sequence Analysis, RNA
Signal Transduction / genetics*
Thailand
Toll-Like Receptors / genetics
Transcriptome
Wound Healing / genetics*
Young Adult

Substances

MicroRNAs
Receptors, Notch
Toll-Like Receptors

Grants and funding

DH_/Department of Health/United Kingdom