[Association of CTLA-4 gene polymorphism in allergic rhinitis with asthma or not in children]

S H Song; X Q Wang; Y Shen; P Wei; S L Hong; X Ke

doi:10.13201/j.issn.1001-1781.2016.20.004

[Association of CTLA-4 gene polymorphism in allergic rhinitis with asthma or not in children]

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Oct 20;30(20):1597-1600. doi: 10.13201/j.issn.1001-1781.2016.20.004.

[Article in Chinese]

Authors

S H Song¹, X Q Wang², Y Shen², P Wei³, S L Hong², X Ke²

Affiliations

¹ Department of Otorhinolaryngology, the First Affiliated Hospital of Chongqing Medical University,Chongqing,400016，China.
² Department of Otorhinolaryngology, the First Affiliated Hospital of Chongqing Medical University,Chongqing,400016,China.
³ Department of Otolaryngology,the Children Hospital of Chongqing Medical University.

PMID: 29871152
DOI: 10.13201/j.issn.1001-1781.2016.20.004

Abstract

Objective:To evaluate the involvement of the cytotoxic T lymphocyte associated antigen (CTLA-4) gene polymorphisms in susceptibility of allergic rhinitis(AR) with/without asthma in children.Method:Three hundred and two AR children,288 AR with asthma children,and 327 healthy Chinese Han children were enrolled in the study.The SNPs of CTLA-4(rs3087243,rs11571302,rs11571315,rs231725,rs35219727,and rs4553808) were sequenced using a PCR restriction fragment length polymorphism assay.Result: An increased frequency of the AA genotype and A allele in rs3087243 of CTLA-4 was found in AR with asthma group.For rs231725,AA genotype and A allele were obviously increased in AR group, while they were significantly decreased in AR with asthma group(P<0.05).Conclusion:We found a significant association between CTLA-4 gene polymorphism and AR with asthma in Chinese Han children, which might be an autoimmunity risk factor for AR with asthma.

Keywords: asthma; child; polymorphism,single nucleotide; rhinitis,allergic; the cytotoxic T-lymphocyte associated antigen 4.

Publication types

English Abstract