Of Mice Not Men? Actions of Interleukin-6 on Glucose Tolerance

Emma R McGlone; Tricia M Tan

doi:10.1016/j.cmet.2018.05.013

Of Mice Not Men? Actions of Interleukin-6 on Glucose Tolerance

Cell Metab. 2018 Jun 5;27(6):1157-1158. doi: 10.1016/j.cmet.2018.05.013.

Authors

Emma R McGlone¹, Tricia M Tan²

Affiliations

¹ Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK.
² Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK. Electronic address: [email protected].

PMID: 29874560
DOI: 10.1016/j.cmet.2018.05.013

Abstract

In mice, interleukin-6 (IL-6) improves glucose tolerance via stimulation of glucagon-like peptide 1 (GLP-1) secretion. In this issue of Cell Metabolism, Lang Lehrskov et al. (2018) demonstrate that IL-6 infusion has GLP-1-dependent and -independent actions with opposing effects on glucose tolerance, resulting in an overall improvement in healthy male volunteers but no improvement in male patients with diabetes.

Publication types

Comment

MeSH terms

Animals
Blood Glucose
Gastric Emptying
Glucagon*
Humans
Insulin
Interleukin-6*
Male
Mice
Peptide Fragments

Substances

Blood Glucose
Insulin
Interleukin-6
Peptide Fragments
Glucagon

Grants and funding

MR/P01870X/1/MRC_/Medical Research Council/United Kingdom