17q21 variant increases the risk of exacerbations in asthmatic children despite inhaled corticosteroids use

Affiliations

• ¹ Division of Pharmacoepidemiology and Clinical Pharmacology, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
• ² Department of Respiratory Medicine, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands.
• ³ Research Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife, Spain.
• ⁴ Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, La Laguna, Tenerife, Spain.
• ⁵ Centre for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor, Maribor, Slovenia.
• ⁶ Clinic of Pediatrics, University Medical Centre Maribor, Maribor, Slovenia.
• ⁷ COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
• ⁸ Departments of Medicine, Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA.
• ⁹ Behavioral Sciences Institute, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico.
• ¹⁰ Division of Pulmonary Medicine, Allergy, and Immunology, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA, USA.
• ¹¹ Department of Biological Sciences, National University of Singapore, Singapore, Singapore.
• ¹² The Allergy & Immunology Division, Department of Paediatric Medicine, KK Children's Hospital, Singapore, Singapore.
• ¹³ Asthma Center, Connecticut Children's Medical Center, University of Connecticut Health Center, Hartford, CT, USA.
• ¹⁴ Department of Women's and Children's Health, University of Liverpool, Liverpool, UK.
• ¹⁵ Alder Hey Children's Hospital, Liverpool, UK.
• ¹⁶ Department of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany.
• ¹⁷ Deptartment of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands.
• ¹⁸ Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
• ¹⁹ Department of Pediatrics, Sachs' Children's Hospital, Stockholm, Sweden.
• ²⁰ Academic Department of Paediatrics, Brighton and Sussex Medical School, Royal Alexandra Children's Hospital, Brighton, UK.
• ²¹ Division of Molecular & Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK.
• ²² CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.
• ²³ Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
• ²⁴ Faculty for Chemistry and Chemical Engineering, University of Maribor, Maribor, Slovenia.
• ²⁵ Department of Human Genetics, Hannover Medical School, Hannover, Germany.
• ²⁶ Institute of Child Health, University College London, London, UK.
• ²⁷ Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
• ²⁸ Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.
• ²⁹ The Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
• ³⁰ Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
• ³¹ Division of Respiratory Medicine, Department of Pediatrics, Sainte-Justine University Hospital Center and University of Montreal, Montreal, QC, Canada.
• ³² Child Health, University of Aberdeen, Aberdeen, UK.