A pilot study of GABAB correlates with resting-state functional connectivity in five depressed female adolescents

Psychiatry Res Neuroimaging. 2018 Sep 30:279:60-63. doi: 10.1016/j.pscychresns.2018.05.013. Epub 2018 May 31.

Abstract

Connectivity features based on resting-state (RS) functional magnetic resonance imaging (fMRI) demonstrate great promise as biomarkers to guide diagnosis and treatment in major depressive disorder (MDD). However, there is a pressing need for valid, reliable biomarkers closer to the bedside for clinical research and practice. This study directly compared RS-fMRI connectivity features with transcranial magnetic stimulation (TMS) neurophysiological measures, long interval cortical inhibition (LICI) and cortical silent period (CSP), in female adolescents with MDD. LICI-200 showed the most significant associations with RS functional connectivity features, demonstrating its potential to evaluate the neurochemical underpinnings of network features in MDD.

Keywords: Connectivity; Depression; Resting state; TMS, fMRI.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Depressive Disorder, Major / diagnostic imaging*
  • Depressive Disorder, Major / metabolism*
  • Depressive Disorder, Major / psychology
  • Female
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Pilot Projects
  • Rest / physiology*
  • Rest / psychology
  • Transcranial Magnetic Stimulation / methods
  • gamma-Aminobutyric Acid / metabolism*

Substances

  • gamma-Aminobutyric Acid