Possible reactivation of chromosomally integrated human herpesvirus 6 after treatment with histone deacetylase inhibitor

Blood Adv. 2018 Jun 26;2(12):1367-1370. doi: 10.1182/bloodadvances.2018015982.

Abstract

  1. HDAC inhibitors might induce ciHHV-6 reactivation.

  2. In ciHHV-6 HSCT recipients posttransplant viral load can estimate persistent host chimerism when the donor is ciHHV-6 negative.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chimerism
  • Female
  • Foscarnet / therapeutic use
  • Hematopoietic Stem Cell Transplantation / methods
  • Herpesvirus 6, Human / physiology*
  • Histone Deacetylase Inhibitors / adverse effects
  • Histone Deacetylase Inhibitors / therapeutic use*
  • Humans
  • Middle Aged
  • Tissue Donors
  • Viral Load
  • Virus Activation / drug effects*

Substances

  • Histone Deacetylase Inhibitors
  • Foscarnet