Genetic polymorphism of glutathione S-transferases: Relevance to neurological disorders

Sreenivasulu Dasari; Sailaja Gonuguntla; Muni Swamy Ganjayi; Suman Bukke; Basha Sreenivasulu; Balaji Meriga

doi:10.1016/j.pathophys.2018.06.001

Genetic polymorphism of glutathione S-transferases: Relevance to neurological disorders

Pathophysiology. 2018 Dec;25(4):285-292. doi: 10.1016/j.pathophys.2018.06.001. Epub 2018 Jun 11.

Authors

Sreenivasulu Dasari¹, Sailaja Gonuguntla², Muni Swamy Ganjayi³, Suman Bukke⁴, Basha Sreenivasulu⁵, Balaji Meriga⁶

Affiliations

¹ Dept. of Biochemistry, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India. Electronic address: [email protected].
² Dept. of Biochemistry, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India. Electronic address: [email protected].
³ Dept. of Biochemistry, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India. Electronic address: [email protected].
⁴ Dept. of Biochemistry, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India. Electronic address: [email protected].
⁵ Dept. of Microbiology, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India. Electronic address: [email protected].
⁶ Dept. of Biochemistry, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India. Electronic address: [email protected].

PMID: 29908890
DOI: 10.1016/j.pathophys.2018.06.001

Abstract

Glutathione S-tranferases (GSTs) are phase II drug metabolizing enzymes, they play crucial role in detoxification of environmental pollutants, carcinogens, drugs, xenobiotics and oxidative stress products. Genetic differences in expression and activity of GSTs are due to the existence of polymorphic alleles which encode them. Because of genetic polymorphism the GST activity has altered that lead to the increased susceptibility for toxic chemical compounds. GST genetic polymorphism is the main reason for many neurological dysfunctions. GST has over expressed in epileptic brain and pi (π) GST has used to predict stroke; mu (μ) and pi (π) GST are over expressed in Alzheimer's disease (AD). Null and single nucleotide polymorphism of GST has associated with many neurodisorders. Over all, it can be concluded that the GST genetic polymorphism has associated with neurodegenerative diseases.

Keywords: Genetic polymorphism; Glutathione S-tranferases; Neurological disorders.

Publication types

Review