Gram-Scale Synthesis of a Bench-Stable 5,5″-Unsubstituted Terpyrrole

J Org Chem. 2018 Aug 17;83(16):9568-9570. doi: 10.1021/acs.joc.8b01333. Epub 2018 Jul 3.

Abstract

The controlled preparation of higher order oligopyrrolic species holds broad utility across the chemical and material sciences. Here, we describe the gram-scale synthesis of a bench-stable 5,5″-unsubstituted terpyrrole in excellent yield via a tandem Suzuki cross-coupling with in situ deprotection. The solution and solid-state stability as well as UV-vis, fluorescence, and single crystal X-ray diffraction structure are also detailed.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chemistry Techniques, Synthetic
  • Drug Stability
  • Pyrroles / chemical synthesis*
  • Pyrroles / chemistry*

Substances

  • Pyrroles