Cerebral Oximetry for Detecting High-mortality Risk Patients with Cryptococcal Meningitis

Background: Cryptococcus is the commonest cause of adult meningitis in Africa, with 50%-70% experiencing increased intracranial pressure. Cerebral oximetry is a noninvasive near-infrared spectroscopy technology to monitor percent regional cerebral tissue oxygenation (rSO₂). We assessed if cerebral oximetry predicts meningitis mortality.

Methods: We performed cerebral oximetry within 14 days of cryptococcal meningitis diagnosis on 121 Ugandans from April 2016 to September 2017. We evaluated baseline rSO₂ association with mortality by multivariable logistic regression and correlation with other clinical factors. We compared groups formed by initial rSO₂ <30% vs ≥30% for longitudinal change with mixed effects models. We measured change in %rSO₂ before and after lumbar puncture (LP).

Results: The median initial rSO₂ (interquartile range) was 36% (29%-42%), and it was <30% in 29% (35/121). For 30-day mortality, the unadjusted odds ratio (per 5% increase in rSO₂) was 0.73 (95% confidence interval [CI], 0.58 to 0.91; P = .005). Those with initial rSO₂ <30% had 3.4 (95% CI, 1.5 to 8.0) higher odds of 30-day mortality than those with initial rSO₂ ≥30%. Hemoglobin correlated with initial rSO₂ (rho = .54; P < .001), but rSO₂ did not correlate with pulse oximetry, intracranial pressure, cerebral perfusion pressure, or quantitative cerebrospinal fluid culture, and rSO₂ was unchanged pre/post-lumbar punctures. The longitudinal rSO₂ measurements change was 15% (95% CI, 12% to 18%) lower in the group with initial rSO₂ <30%.

Conclusions: Individuals with cryptococcal meningitis and low cerebral oximetry (rSO₂ < 30%) have high mortality. Cerebral oximetry may be useful as a prognostic marker of mortality. Targeted interventions to improve rSO₂ should be tested in trials to try to decrease mortality in meningitis.