An Overview of Molecular Profiles in Ulcerative Colitis-Related Cancer

Meng Xue; Liuhong Shi; Weijia Wang; Shujie Chen; Liangjing Wang

doi:10.1093/ibd/izy221

An Overview of Molecular Profiles in Ulcerative Colitis-Related Cancer

Inflamm Bowel Dis. 2018 Aug 16;24(9):1883-1894. doi: 10.1093/ibd/izy221.

Authors

Meng Xue^{1

2}, Liuhong Shi³, Weijia Wang⁴, Shujie Chen⁵, Liangjing Wang^{1

2}

Affiliations

¹ Department of Gastroenterology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
² Institute of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang, China.
³ Department of Ultrasound, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
⁴ Department of Cardiology, School of Medicine, the Johns Hopkins Hospital, Baltimore, Maryland.
⁵ Department of Gastroenterology, Sir Runrun Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

PMID: 29945208
DOI: 10.1093/ibd/izy221

Abstract

Ulcerative colitis (UC) is an independent risk factor of colorectal cancer (CRC). Both genetic and epigentic events induce a unique molecular profile during the development from UC to UC-related CRC (UCRC). These molecular changes play varied roles in DNA repair, immune response, cell metabolism, and interaction with the microbiota during the carcinogenesis process. This review will systmatically discuss the molecular characteristics of UCRC and point out the future perspectives in this research field.

Keywords: colorectal cancer; epigenetics; genetics; gut microbiota; molecule; ulcerative colitis.

Publication types

Review

MeSH terms

Carcinogenesis / genetics*
Cell Transformation, Neoplastic / genetics
Colitis, Ulcerative / complications
Colitis, Ulcerative / genetics*
Colorectal Neoplasms / genetics*
DNA Methylation / genetics
Humans
Risk Factors