Abstract
Persistent infection with virulent canine distemper virus (CDV-SH) was established in 2 human lymphoblastoid B cell lines (Wi-L2 and Raji), and one human (HSB), one simian (1670) and one canine (CT-45-S) lymphoblastoid T cell line. Cell free virus from persistently infected T cell lines was avirulent for dogs but virulence was maintained during 31 cell passages in persistently infected B cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Viral / analysis
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Antigens, Viral / analysis
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Cell Line
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Distemper / pathology
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Distemper Virus, Canine / growth & development*
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Distemper Virus, Canine / isolation & purification
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Distemper Virus, Canine / pathogenicity
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Dogs
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Herpesvirus 4, Human / immunology
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Humans
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Lymphocytes / microbiology*
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Virulence
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Virus Replication
Substances
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Antibodies, Viral
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Antigens, Viral