Early cannulation of bovine carotid artery grafts (Artegraft) after primary vascular access and fistula revision procedures

J Vasc Surg. 2018 Dec;68(6):1865-1871. doi: 10.1016/j.jvs.2018.04.061. Epub 2018 Jun 28.

Abstract

Objective: Tunneled dialysis catheter (TDC) use has been associated with increased infectious complications and mortality in hemodialysis-dependent patients. Unfortunately, patients who undergo fistula revisions or creation of a new arteriovenous fistula frequently require a TDC during the postoperative period. Bovine carotid artery grafts (BCAGs) can be used as an early-access dialysis conduit to reduce TDC dependence. This study describes the performance of BCAGs that were cannulated early (<3 days) after implantation and associated clinical outcomes.

Methods: BCAGs were implanted in 63 consecutive dialysis-dependent patients. Patients and dialysis centers were directly provided early cannulation instructions; 31 (49%) patients were cannulated early, and of the 31 patients cannulated early, 21 (68%) were cannulated during the first postoperative day. Early complications, primary patency, secondary patency, and TDC incidence were monitored through clinic visits, hospital records, and phone calls to dialysis centers.

Results: The primary patency of BCAGs at 1 year in the early and late cannulation cohorts was 28% and 39%, respectively. The secondary patency of BCAGs at 1 year in the early and late cannulation cohorts was 74% and 77%, respectively. Early complications occurred in 11 (19%) patients who received a BCAG. There were no significant differences in complication rates between early and late cannulation patients. Of the 24 patients who underwent the operation without a pre-existing TDC, only three (13%) required TDC placement during the 30-day postoperative period.

Conclusions: BCAGs can be cannulated early without increased complication rates or a negative impact on midterm patency. Early cannulation of BCAGs obviates the need for a TDC postoperatively in dialysis-dependent patients undergoing primary vascular access or fistula revision procedures.

Keywords: BCAG; Bovine; Early cannulation; Vascular access.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Animals
  • Arteriovenous Shunt, Surgical* / adverse effects
  • Bioprosthesis*
  • Blood Vessel Prosthesis Implantation / adverse effects
  • Blood Vessel Prosthesis Implantation / instrumentation*
  • Blood Vessel Prosthesis*
  • Carotid Arteries / transplantation*
  • Catheterization
  • Catheterization, Central Venous
  • Cattle
  • Female
  • Graft Occlusion, Vascular / etiology
  • Graft Occlusion, Vascular / physiopathology
  • Heterografts
  • Humans
  • Male
  • Middle Aged
  • Prosthesis Design
  • Renal Dialysis*
  • Retrospective Studies
  • Risk Factors
  • Time Factors
  • Treatment Outcome
  • Upper Extremity / blood supply*
  • Vascular Patency