Sensorineural Deafness Following Tacrolimus Use

Exp Clin Transplant. 2020 Feb;18(1):110-111. doi: 10.6002/ect.2017.0114. Epub 2018 Jul 2.

Abstract

Early trials of tacrolimus in renal transplant recipients have not revealed hearing loss as an adverse effect. Here, we present a case report and a review of the literature of deafness after tacrolimus use. The review of the literature and our experience suggested that the possible reason for hearing loss could be due to an initiation of a sudden spike in the tacrolimus serum level, which was later worsened by its cumulative toxic effect.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Calcineurin Inhibitors / adverse effects*
  • Hearing / drug effects*
  • Hearing Loss, Sensorineural / chemically induced*
  • Hearing Loss, Sensorineural / diagnosis
  • Hearing Loss, Sensorineural / physiopathology
  • Humans
  • Immunosuppressive Agents / adverse effects*
  • Kidney Transplantation / adverse effects*
  • Male
  • Middle Aged
  • Ototoxicity
  • Tacrolimus / administration & dosage*
  • Treatment Outcome

Substances

  • Calcineurin Inhibitors
  • Immunosuppressive Agents
  • Tacrolimus