In vitro inhibition of renal sodium-potassium ATPase activity by progesterone

Methods Find Exp Clin Pharmacol. 1985 Jul;7(7):347-9.

Abstract

The effect of various steroids and prostaglandins on the activity of canine kidney Na+, K+-ATPase activity was tested in vitro. Progesterone induced a dose-dependent increase in inhibition of the canine kidney Na+, K+-ATPase activity. Aldosterone, cortisol, cortisone as well as prostaglandin E2 and 13,14-dihydro-15-keto-prostaglandin F2 alpha, did not cause an inhibition of canine kidney Na+, K+-ATPase.

MeSH terms

  • Aldosterone / pharmacology
  • Animals
  • Dogs
  • Dose-Response Relationship, Drug
  • In Vitro Techniques
  • Kidney / enzymology*
  • Progesterone / pharmacology*
  • Prostaglandins / pharmacology
  • Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors*

Substances

  • Prostaglandins
  • Aldosterone
  • Progesterone
  • Sodium-Potassium-Exchanging ATPase