Chronic Meningitis and Hydrocephalus due to Sporothrix brasiliensis in Immunocompetent Adults: A Challenging Entity

Rafael Mialski; João Nobrega de Almeida Jr; Larissa Honorato da Silva; Adriana Kono; Rosangela Lameira Pinheiro; Manoel Jacobsen Teixeira; Renata Rodrigues Gomes; Flávio de Queiroz-Telles; Fernando Gomes Pinto; Gil Benard

doi:10.1093/ofid/ofy081

Chronic Meningitis and Hydrocephalus due to Sporothrix brasiliensis in Immunocompetent Adults: A Challenging Entity

Open Forum Infect Dis. 2018 May 28;5(5):ofy081. doi: 10.1093/ofid/ofy081. eCollection 2018 May.

Affiliations

¹ Ônix Hospital, Paraná State Health Department, Curitiba, Brazil.
² Infectology Sector, Clinics Hospital, Federal University of Paraná, Curitiba, Brazil.
³ Central Laboratory Division, LIM-03, Clinics Hospital, São Paulo University, São Paulo, Brazil.
⁴ Laboratory of Medical Mycology, LIM-53, Clinics Hospital and Tropical Medicine Institute, São Paulo University, São Paulo, Brazil.
⁵ Microbiology Sector, Bom Jesus Laboratory, Curitiba, Brazil.
⁶ Infectious Diseases Division, Clinics Hospital, São Paulo University, São Paulo, Brazil.
⁷ Micology Laboratory, Clinics Hospital, Federal University of Paraná, Curitiba, Brazil.
⁸ Neurology Department, Clinics Hospital, São Paulo University, São Paulo, Brazil.
⁹ Microbiology Laboratory, Federal University of Paraná, Curitiba, Brazil.
¹⁰ Neurosurgery Department, Clinics Hospital, Medical School, São Paulo University, São Paulo, Brazil.

Abstract

Chronic meningitis caused by Sporothrix sp. is occasionally described in immunosuppressed patients. We report the challenges in diagnosing and managing 2 nonimmunocompromised patients with hydrocephalus and chronic meningitis caused by Sporothrix brasiliensis. This more virulent species appears to contribute more atypical and severe cases than other related species.

Keywords: CNS; Sporothrix brasiliensis; Sporotrichosis; chronic meningitis; hydrocephalus; virulence.