Vismodegib-resistant basal cell carcinomas in basal cell nevus syndrome: Clinical approach and genetic analysis

Kelly A E Sinx; Guido M J M Roemen; Virrie van Zutven; Renske Janssen; Ernst-Jan M Speel; Peter M Steijlen; Michel van Geel; Klara Mosterd

doi:10.1016/j.jdcr.2017.11.011

Vismodegib-resistant basal cell carcinomas in basal cell nevus syndrome: Clinical approach and genetic analysis

JAAD Case Rep. 2018 Apr 30;4(5):408-411. doi: 10.1016/j.jdcr.2017.11.011. eCollection 2018 Jun.

Authors

Kelly A E Sinx^{1

2}, Guido M J M Roemen³, Virrie van Zutven¹, Renske Janssen^{1

2}, Ernst-Jan M Speel^{2

3}, Peter M Steijlen^{1

2}, Michel van Geel^{1

2

4}, Klara Mosterd^{1

2}

Affiliations

¹ Department of Dermatology, Maastricht University Medical Centre, Maastricht, The Netherlands.
² GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands.
³ Department of Pathology, Maastricht University Medical Centre, Maastricht, The Netherlands.
⁴ Department of Clinical Genetics, Maastricht University Medical Centre, Maastricht, The Netherlands.

No abstract available

Keywords: BCC, basal cell carcinoma; BCNS, basal cell nevus syndrome; SHH, sonic hedgehog pathway; basal cell carcinoma; basal cell nevus syndrome; hedgehog pathway; laBCC, locally advanced BCC; mBCC, metastatic BCC; smMIP, single-molecule molecular inversion probes; tumor resistance; vismodegib.

Publication types

Case Reports