Successful treatment of massive pulmonary embolism with low-dose tissue plasminogen activator after meniscus surgery

Blood Coagul Fibrinolysis. 2018 Sep;29(6):559-561. doi: 10.1097/MBC.0000000000000754.

Abstract

: Pulmonary embolism is a life-threatening disease which represents with high mortality and morbidity. Systemic fibrinolysis is the first-line recommended therapy in hemodynamically instable patients with massive pulmonary embolism. Systemic fibrinolytic treatment remains controversial for pulmonary embolism after surgery due to high risk of hemorrhage. Herein, we report a 49-year-old man with massive pulmonary embolism after meniscus surgery, successfully treated with low-dose prolonged infusion of tissue type plasminogen activator.

Publication types

  • Case Reports

MeSH terms

  • Anticoagulants / administration & dosage
  • Anticoagulants / therapeutic use
  • Fibrinolytic Agents / administration & dosage
  • Fibrinolytic Agents / therapeutic use*
  • Heparin / administration & dosage
  • Heparin / therapeutic use
  • Humans
  • Male
  • Meniscus / surgery*
  • Middle Aged
  • Orthopedic Procedures / adverse effects*
  • Pulmonary Embolism / blood
  • Pulmonary Embolism / drug therapy*
  • Pulmonary Embolism / etiology*
  • Pulmonary Embolism / pathology
  • Tissue Plasminogen Activator / administration & dosage
  • Tissue Plasminogen Activator / therapeutic use*
  • Warfarin / administration & dosage
  • Warfarin / therapeutic use

Substances

  • Anticoagulants
  • Fibrinolytic Agents
  • Warfarin
  • Heparin
  • Tissue Plasminogen Activator