Development and Interlaboratories Validation of Event-Specific Quantitative Real-Time PCR Method for Genetically Modified Rice G6H1 Event

J Agric Food Chem. 2018 Aug 1;66(30):8179-8186. doi: 10.1021/acs.jafc.8b01519. Epub 2018 Jul 18.

Abstract

The transgenic rice G6H1 was a new event with the traits of herbicide-tolerance and insect-resistant. Herein, we developed one event-specific real-time PCR method with high specificity and sensitivity for G6H1 event quantitative analysis, and validated its performance on practical samples quantification through a collaborative ring trial. A total of eight laboratories participated in this validation and quantified three blind G6H1 powder samples including DNA extraction and real-time PCR analysis. The statistically analyzed results from returned data confirmed its high PCR efficiency and good linearity, trueness, and precision, indicating that the developed G6H1 real-time PCR assay was accurate, reliable, and comparable for G6H1 identification and quantification.

Keywords: collaborative ring trial; real-time PCR; transgenic rice G6H1.

Publication types

  • Evaluation Study

MeSH terms

  • DNA, Plant / genetics
  • Oryza / genetics*
  • Plants, Genetically Modified / genetics*
  • Real-Time Polymerase Chain Reaction / methods*
  • Sensitivity and Specificity

Substances

  • DNA, Plant