Abstract
Many human tumors have been shown to exhibit cytologic evidence of gene amplification. In several instances the amplified genes have proven to be cellular oncogenes. We present an approach for combining cytogenetic and molecular biological techniques to systematically investigate this phenomenon.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Base Sequence
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Cells, Cultured
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DNA / genetics
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DNA Restriction Enzymes
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DNA, Neoplasm / genetics
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Electrophoresis, Agar Gel
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Gene Amplification*
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Humans
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Karyotyping
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Neoplasms / genetics*
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Oncogenes*
Substances
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DNA, Neoplasm
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DNA
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DNA Restriction Enzymes