Early stage memory impairment, visual hallucinations, and myoclonus combined with temporal lobe atrophy predict Alzheimer's disease pathology in corticobasal syndrome

Neurocase. 2018 Jun;24(3):145-150. doi: 10.1080/13554794.2018.1494290. Epub 2018 Jul 10.

Abstract

Corticobasal syndrome (CBS) is a typical phenotype of corticobasal degeneration (CBD). However, autopsy series have shown that many CBS cases emerge from various types of non-CBD pathology. We report a 73-year-old Korean man who was clinically diagnosed with CBS whose underlying pathology was Alzheimer's disease (AD) at autopsy (CBS-AD). This case suggests that early developing memory impairment and myoclonus, severe temporoparietal atrophy, and visual hallucinations may support a more specific prediction of CBS-AD.

Keywords: Alzheimer’s disease pathology; Corticobasal syndrome; atypical Alzheimer’s dementia; corticobasal degeneration; myoclonus; visual hallucination.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alzheimer Disease / complications
  • Alzheimer Disease / diagnosis*
  • Alzheimer Disease / pathology
  • Atrophy / pathology
  • Autopsy
  • Hallucinations / diagnosis*
  • Hallucinations / etiology
  • Humans
  • Male
  • Memory Disorders / diagnosis*
  • Memory Disorders / etiology
  • Myoclonus / diagnosis*
  • Myoclonus / etiology
  • Parkinsonian Disorders / complications
  • Parkinsonian Disorders / diagnosis*
  • Parkinsonian Disorders / pathology
  • Temporal Lobe / pathology*