Cryptic ETV6-PDGFRB fusion in a highly complex rearrangement of chromosomes 1, 5, and 12 due to a chromothripsis-like event in a myelodysplastic syndrome/myeloproliferative neoplasm

Leuk Lymphoma. 2019 May;60(5):1304-1307. doi: 10.1080/10428194.2018.1480774. Epub 2018 Jul 11.

Authors

Affiliations

¹ a Department of Pathology , Greenebaum Comprehensive Cancer Center, University of Maryland , Baltimore , MD , USA.
² b Department of Medicine , Greenebaum Comprehensive Cancer Center, University of Maryland , Baltimore , MD , USA.
³ c Department of Laboratory Medicine and Pathology , Mayo Clinic , Rochester , MN , USA.

PMID: 29992858
DOI: 10.1080/10428194.2018.1480774

No abstract available

Publication types

Letter

MeSH terms

Antineoplastic Combined Chemotherapy Protocols / adverse effects
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Biopsy
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 5
Chromothripsis*
Combined Modality Therapy / adverse effects
Combined Modality Therapy / methods
Gene Rearrangement*
Humans
Karyotype
Myelodysplastic-Myeloproliferative Diseases / diagnosis
Myelodysplastic-Myeloproliferative Diseases / genetics*
Myelodysplastic-Myeloproliferative Diseases / therapy
Oncogene Proteins, Fusion / genetics*
Translocation, Genetic*

Substances

ETV6-PDGFRB fusion protein, human
Oncogene Proteins, Fusion