Progress in high-sensitivity hybrid LC-MS/MS methods for the bioanalysis of protein drugs and performance tests for their validation

Bioanalysis. 2018 Jul 1;10(13):983-986. doi: 10.4155/bio-2018-0090. Epub 2018 Jul 11.
No abstract available

Keywords: GXP bioanalysis; LC–MS bioanalysis of protein drugs; assay matrix effects; bioanalytical selectivity; bioanalytical validation; digestion efficiency; hybrid bioanalysis; immunocapture; protein bioanalysis; protein drug validation; regulated bioanalysis; sequential protein peptide immunocapture.

Publication types

  • Editorial

MeSH terms

  • Animals
  • Chromatography, Liquid / methods*
  • Humans
  • Immunoassay
  • Limit of Detection*
  • Proteins / analysis*
  • Proteins / chemistry
  • Proteins / therapeutic use
  • Reproducibility of Results
  • Tandem Mass Spectrometry / methods*
  • Validation Studies as Topic

Substances

  • Proteins