Objective: To investigate the association between anthropometry and colorectal cancer risk in Chinese males. Methods: Anthropometry and incident colorectal cancer cases were collected on a biennial basis starting in May 2006 among males in Kailuan Cohort (2006-2014). In addition, electronic database of hospitals affiliated to Kailuan Community, Insurance System of Kailuan Community and Tangshan were also searched for supplementary information. Cox proportional hazards regression models and linear models were used to evaluate the association between baseline anthropometry and the risk of colorectal cancer in males. Results: A total of 106 786 males were included and 318 new colorectal cancer cases were identified in the Kailuan male cohort study, with 747 337.60 person-years follow-up by 31 December 2014. The median follow-up time was 7.90 years. Highest quartile waist circumference (≥94.0 cm) or WHtR (≥0.55) had 1.45 (95%CI: 1.05-2.02) and 1.66 (95%CI: 1.15-2.41) higher risk of colorectal cancer when compared with lowest waist circumference (<82.0 cm) or WHtR (<0.48) after adjusting for age, education, smoking, alcohol drinking, sitting time and dust exposure. Subgroup analyses by site indicated that males with BMI ≥26.27 kg/m(2), waist circumference ≥94.0 cm or WHtR ≥0.55 had HRs (95%CI) of 2.18(1.27-3.73), 2.20 (1.27-3.78) and 2.42 (1.29-4.56) for colon cancer risk, respectively. Linear models showed the HR of colon cancer and 95%CI would be 1.59 (1.24-2.02) with every 0.1 growth in WHtR. Conclusion: Obesity may be responsible for an increased risk of colorectal cancer in male. Reasonable weight control may be one of the effective measures to prevent colorectal cancer.
目的： 研究我国男性身体测量指标与结直肠癌发病之间的关系。 方法： 2006年5月建立开滦集团动态队列，于2006-2014年间，每两年对队列中男性人群进行随访，收集身体测量指标及结直肠癌发病结局资料。同时检索开滦附属医院医疗信息系统、开滦集团保险系统、唐山市医疗保险系统，补充收集随访过程中可能遗漏的结直肠癌新发病例。所有基线身体测量指标均按照四分位法进行分组，并以第一分位为参比组，采用Cox风险比例回归模型分析身高、体重、BMI、腰围、腰围身高比（WHtR）等身体测量指标与男性结直肠癌发病风险的关联，计算发病HR和95%CI，并对各测量指标进行线性趋势分析。 结果： 共有106 786名男性被纳入研究，共随访747 337.60人年，中位随访时间为7.90年，共收集结直肠癌新发病例318例。调整年龄、教育水平、吸烟、饮酒、每天坐位时间、粉尘暴露史等混杂因素后，与腰围<82.0 cm、WHtR<0.48人群相比，高腰围（≥94.0 cm）与高WHtR（≥0.55）人群结直肠癌发病HR（95%CI）值分别为1.45（1.05~2.02）和1.66（1.15~2.41）。按发病部位分层分析后发现，与BMI<22.06 kg/m(2)、腰围<82.0 cm、WHtR<0.48男性人群相比，BMI≥26.27 kg/m(2)、腰围≥94.0 cm和WHtR≥0.55男性人群患结肠癌的HR（95%CI）值分别为2.18(1.27~3.73)、2.20（1.27~3.78）和2.42（1.29~4.56）。线性趋势分析显示，WHtR每增加0.1，结肠癌发病风险HR（95%CI）值为1.59（1.24~2.02）。 结论： 肥胖与男性结直肠癌发生密切相关，合理控制体重可能是预防和控制男性结直肠癌的有效措施之一。.
Keywords: Anthropometry; Cohort study; Colorectal neoplasms; Male.