Abstract
In a double-blind placebo-controlled trial POLYNCOR (registration No. NCT03122340 at clinicaltrials.gov ), lipid-lowering and hepatoprotective effects of polyprenol-containing drug Ropren were evaluated in patients with acute coronary syndrome. After 2-months therapy, total cholesterol and ALT in the patients receiving Ropren were significantly (p<0.05) lower than in the control group. The number of patients who needed to discontinue or reduce the dose of atorvastatin due to an increase in the level of transaminases in the main group was significantly (p<0.05) lower than in the control group: 0 (0%) vs. 5 (33.3%). The more pronounced decrease in cholesterol level and hepatoprotective effect of Ropren allowed recommending this preparation to patients with acute coronary syndrome in addition to standard therapy.
Keywords:
Ropren; acute coronary syndrome; polyprenols; statin.
Publication types
-
Randomized Controlled Trial
MeSH terms
-
Acute Coronary Syndrome / blood
-
Acute Coronary Syndrome / drug therapy*
-
Acute Coronary Syndrome / mortality
-
Acute Coronary Syndrome / physiopathology
-
Aged
-
Alanine Transaminase / blood
-
Alkaline Phosphatase / blood
-
Aspartate Aminotransferases
-
Atorvastatin / therapeutic use
-
Cholesterol / blood
-
Cholesterol, HDL / blood
-
Cholesterol, LDL / blood
-
Double-Blind Method
-
Female
-
Humans
-
Hyperlipidemias / blood
-
Hyperlipidemias / drug therapy*
-
Hyperlipidemias / mortality
-
Hyperlipidemias / physiopathology
-
Hypolipidemic Agents / therapeutic use*
-
Male
-
Middle Aged
-
Plant Extracts / therapeutic use*
-
Survival Analysis
-
Triglycerides / blood
-
gamma-Glutamyltransferase / blood
Substances
-
Cholesterol, HDL
-
Cholesterol, LDL
-
Hypolipidemic Agents
-
Plant Extracts
-
Ropren
-
Triglycerides
-
Cholesterol
-
Atorvastatin
-
gamma-Glutamyltransferase
-
Aspartate Aminotransferases
-
Alanine Transaminase
-
Alkaline Phosphatase
Associated data
-
ClinicalTrials.gov/NCT03122340