Silk fibroin nanoparticles as biocompatible nanocarriers of a novel light-responsive CO-prodrug

Dalton Trans. 2018 Aug 21;47(31):10434-10438. doi: 10.1039/c8dt02125b. Epub 2018 Jul 12.

Abstract

[Mn(CO)3(2,2'-bipyridine)(PPh3)](ClO4) (1), a novel photoactive CO-releasing molecule, has been prepared and fully characterized. Besides, silk fibroin nanoparticles (SFNs) have been used, for the first time, as vehicles of 1 leading to the hybrid material 1@SFNs that shows an enhanced CO-delivery.

MeSH terms

  • 2,2'-Dipyridyl / chemistry
  • Biocompatible Materials / chemical synthesis
  • Biocompatible Materials / chemistry*
  • Carbon Monoxide / chemistry*
  • Carbonates / chemistry
  • Drug Carriers / chemical synthesis
  • Drug Carriers / chemistry*
  • Fibroins / chemistry*
  • Manganese / chemistry
  • Molecular Structure
  • Nanoparticles / chemistry*
  • Organophosphorus Compounds / chemistry
  • Perchlorates / chemistry
  • Photosensitizing Agents
  • Prodrugs / chemistry*

Substances

  • Biocompatible Materials
  • Carbonates
  • Drug Carriers
  • Organophosphorus Compounds
  • Perchlorates
  • Photosensitizing Agents
  • Prodrugs
  • triphenylphosphine
  • Manganese
  • 2,2'-Dipyridyl
  • Carbon Monoxide
  • Fibroins
  • manganese carbonate
  • perchlorate