A Cross-sectional Study to Compare Hepatitis B Immunity in HIV-infected and HIV-uninfected Kenyan Children After Primary Hepatitis B Immunization

Pediatr Infect Dis J. 2018 Aug;37(8):e214-e215. doi: 10.1097/INF.0000000000001902.

Abstract

To evaluate protective antibody levels against hepatitis B surface antigen in HIV-infected and HIV-uninfected Kenyan children, this study enrolled 531 children. In the HIV-infected group, only 18.3% had protective hepatitis B surface antigen compared with 74.4% in the HIV-uninfected group (P < 0.0001). Perhaps HIV-infected children should be immunized differently.

Publication types

  • Comparative Study

MeSH terms

  • Age Factors
  • Child
  • Child, Preschool
  • Cross-Sectional Studies
  • Female
  • HIV
  • HIV Infections / epidemiology*
  • Hepatitis B / epidemiology
  • Hepatitis B / immunology*
  • Hepatitis B Antibodies / blood*
  • Hepatitis B Surface Antigens / immunology*
  • Hepatitis B Vaccines / administration & dosage*
  • Hepatitis B Vaccines / immunology
  • Humans
  • Immunization Schedule
  • Infant
  • Kenya / epidemiology
  • Male

Substances

  • Hepatitis B Antibodies
  • Hepatitis B Surface Antigens
  • Hepatitis B Vaccines