Chemokines in pregnant women with sickle cell disease

Manuela Freire Hazin-Costa; Aderson da Silva Aráujo; Glaucia Lins Guerra; Marina Cadena da Matta; Leuridan Cavalcante Torres; Ariani Impieri Souza

doi:10.1016/j.cyto.2018.07.002

Chemokines in pregnant women with sickle cell disease

Cytokine. 2019 Jan:113:195-199. doi: 10.1016/j.cyto.2018.07.002. Epub 2018 Jul 10.

Authors

Manuela Freire Hazin-Costa¹, Aderson da Silva Aráujo², Glaucia Lins Guerra³, Marina Cadena da Matta³, Leuridan Cavalcante Torres³, Ariani Impieri Souza⁴

Affiliations

¹ Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Rua dos Coelhos, 300, Boa Vista, 50.070-550 Recife, Pernambuco, Brazil; Fundação de Hematologia e Hemoterapia de Pernambuco HEMOPE, Rua Joaquim Nabuco, 171, Graças, 52.011-000 Recife, Pernambuco, Brazil; Universidade Federal de Pernambuco (UFPE), Av. Prof. Moraes Rego, 1235, Cidade Universitária, 50.670-90 Recife, Pernambuco, Brazil. Electronic address: [email protected].
² Fundação de Hematologia e Hemoterapia de Pernambuco HEMOPE, Rua Joaquim Nabuco, 171, Graças, 52.011-000 Recife, Pernambuco, Brazil.
³ Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Rua dos Coelhos, 300, Boa Vista, 50.070-550 Recife, Pernambuco, Brazil.
⁴ Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Rua dos Coelhos, 300, Boa Vista, 50.070-550 Recife, Pernambuco, Brazil; Faculdade Pernambucana de Saúde (FPS), Av. Mal. Mascarenhas de Morais, 4861, Imbiribeira, 51.180-001 Recife, Pernambuco, Brazil.

PMID: 30006250
DOI: 10.1016/j.cyto.2018.07.002

Abstract

Pregnancy in sickle cell disease is a problem due to the adverse outcomes related to the disease. Research into the role of chemokines in sickle cell disease is available, but studies investigating the disease in pregnancy are scarce. Our data show the chemokine profiles of pregnant women with sickle cell disease compared with control groups. There were no differences in MCP-1 level among the groups, but IL-8 and MIG were likely related with disease activity. In addition, levels of IP-10 were higher in pregnant women with sickle cell disease and, interestingly, RANTES levels were higher in normal pregnancy when compared to pregnancy in sickle cell disease. More studies should be encouraged to fully elucidate chemokine activity during pregnancy in sickle cell disease.

Keywords: Chemokines; Pregnancy; Sickle cell disease.

Publication types

Clinical Trial
Comparative Study

MeSH terms

Adolescent
Adult
Anemia, Sickle Cell / blood*
Chemokines / blood*
Female
Humans
Pregnancy
Pregnancy Complications, Hematologic / blood*
Prospective Studies

Substances

Chemokines