Overuse of inhaled corticosteroids in COPD: five questions for withdrawal in daily practice

Int J Chron Obstruct Pulmon Dis. 2018 Jul 5:13:2089-2099. doi: 10.2147/COPD.S164259. eCollection 2018.

Abstract

Evidence and guidelines are becoming increasingly clear about imbalance between the risks and benefits of inhaled corticosteroids (ICSs) in patients with COPD. While selected patients may benefit from ICS-containing regimens, ICSs are often inappropriately prescribed with - according to Belgian market research data - up to 70% of patients in current practice receiving ICSs, usually as a fixed combination with a long-acting β2-adrenoreceptor agonist. Studies and recommendations support withdrawal of ICSs in a large group of patients with COPD. However, historical habits appear difficult to change even in the light of recent scientific evidence. We have built a collaborative educational platform with chest physicians and primary care physicians to increase awareness and provide guidance and support in this matter.

Keywords: COPD; education; exacerbation; inhaled steroids; systematic review; withdrawal.

Publication types

  • Review

MeSH terms

  • Administration, Inhalation
  • Adrenal Cortex Hormones / administration & dosage*
  • Asthma / complications
  • Asthma / drug therapy
  • Bronchodilator Agents / administration & dosage*
  • Drug Therapy, Combination
  • Humans
  • Inappropriate Prescribing / prevention & control*
  • Prescription Drug Overuse / prevention & control*
  • Pulmonary Disease, Chronic Obstructive / complications
  • Pulmonary Disease, Chronic Obstructive / drug therapy*
  • Withholding Treatment*

Substances

  • Adrenal Cortex Hormones
  • Bronchodilator Agents