Viral Infection "Interferes" with Glucose Tolerance

Kaitlin Kiernan; Nancie J MacIver

doi:10.1016/j.immuni.2018.06.013

Viral Infection "Interferes" with Glucose Tolerance

Immunity. 2018 Jul 17;49(1):6-8. doi: 10.1016/j.immuni.2018.06.013.

Authors

Kaitlin Kiernan¹, Nancie J MacIver²

Affiliations

¹ Department of Immunology, Duke University, Durham, NC, USA.
² Department of Immunology, Duke University, Durham, NC, USA; Department of Pediatrics, Duke University, Durham, NC, USA; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA. Electronic address: [email protected].

PMID: 30021147
DOI: 10.1016/j.immuni.2018.06.013

Abstract

In this issue of Immunity, Šestan et al. (2018) show that viral-induced inflammation leads to insulin resistance in skeletal muscle, followed by compensatory hyperinsulinemia, which promotes the anti-viral effector response of CD8⁺ T cells. Interestingly, this leads to persistent glucose intolerance and the progression of type 2 diabetes in pre-diabetic animals.

Publication types

Comment

MeSH terms

Animals
Diabetes Mellitus, Type 2*
Insulin
Insulin Resistance*
Interferon-gamma
Muscle, Skeletal
Obesity

Substances

Insulin
Interferon-gamma

Abstract

Publication types

MeSH terms

Substances

Grants and funding