Ibrutinib blocks Btk-dependent NF-ĸB and NFAT responses in human macrophages during Aspergillus fumigatus phagocytosis

Blood. 2018 Nov 1;132(18):1985-1988. doi: 10.1182/blood-2017-12-823393. Epub 2018 Jul 18.

Abstract

Publisher's Note: There is a Blood Commentary on this article in this issue.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenine / analogs & derivatives
  • Agammaglobulinaemia Tyrosine Kinase / antagonists & inhibitors*
  • Agammaglobulinaemia Tyrosine Kinase / immunology
  • Aspergillosis / immunology*
  • Aspergillus fumigatus / immunology*
  • Cells, Cultured
  • Humans
  • Macrophages / drug effects*
  • Macrophages / immunology
  • Macrophages / microbiology
  • NF-kappa B / immunology*
  • NFATC Transcription Factors / immunology*
  • Phagocytosis / drug effects
  • Piperidines
  • Pyrazoles / adverse effects*
  • Pyrimidines / adverse effects*

Substances

  • NF-kappa B
  • NFATC Transcription Factors
  • Piperidines
  • Pyrazoles
  • Pyrimidines
  • ibrutinib
  • Agammaglobulinaemia Tyrosine Kinase
  • BTK protein, human
  • Adenine