Recurring acute urticaria and abdominal pain: Consider a diagnosis of alpha-galactose anaphylaxis

Ann Dermatol Venereol. 2018 Nov;145(11):690-693. doi: 10.1016/j.annder.2018.06.001. Epub 2018 Jul 20.

Abstract

Background: Food urticaria is common and generally benign, and it may be of viral or idiopathic aetiology. A food origin of the allergy is frequently sought but rarely found. Mammalian meat anaphylaxis, or alpha-galactose (α-gal) anaphylaxis, is a rare and recently discovered entity.

Patients and methods: Herein, we report a case of alpha-galactose (α-gal) anaphylaxis in a 60-year-old woman presenting four episodes of acute urticaria with signs of anaphylaxis occurring a few hours after meals containing mammalian meat (beef meat, pork meat and offal). The diagnosis was confirmed by a positive gelatine prick-test and the presence of α-gal IgE.

Discussion: In the event of acute urticaria associated with systemic symptoms, in particular gastrointestinal signs, allergy to α-galactose should be considered.

Keywords: Alpha-galactose; Anaphylaxie; Anaphylaxis; Meat; Tick; Tique; Urticaire; Urticaria; Viande.

Publication types

  • Case Reports

MeSH terms

  • Abdominal Pain / etiology*
  • Animals
  • Female
  • Food Hypersensitivity / diagnosis*
  • Food Hypersensitivity / etiology
  • Galactose / adverse effects*
  • Humans
  • Meat / adverse effects
  • Middle Aged
  • Recurrence
  • Urticaria / etiology*

Substances

  • Galactose