The Epitranscriptome in Translation Regulation

Cold Spring Harb Perspect Biol. 2019 Aug 1;11(8):a032623. doi: 10.1101/cshperspect.a032623.

Abstract

The cellular proteome reflects the total outcome of many regulatory mechanisms that affect the metabolism of messenger RNA (mRNA) along its pathway from synthesis to degradation. Accumulating evidence in recent years has uncovered the roles of a growing number of mRNA modifications in every step along this pathway, shaping translational output. mRNA modifications affect the translation machinery directly, by influencing translation initiation, elongation and termination, or by altering mRNA levels and subcellular localization. Features of modification-related translational control are described, charting a new and complex layer of translational regulation.

Publication types

  • Review

MeSH terms

  • Adenosine / analogs & derivatives
  • Adenosine / chemistry
  • Animals
  • Cytidine / analogs & derivatives
  • Cytidine / chemistry
  • Epigenomics*
  • Gene Expression Regulation*
  • Homeostasis
  • Humans
  • Methylation
  • Peptide Chain Elongation, Translational
  • Peptide Chain Initiation, Translational
  • Protein Biosynthesis
  • Pseudouridine / chemistry
  • RNA, Messenger / chemistry
  • RNA, Transfer / chemistry
  • Transcription, Genetic*
  • Transcriptome*

Substances

  • 5-hydroxymethylcytidine
  • RNA, Messenger
  • Pseudouridine
  • 1-methyladenosine
  • N(6),O(2)-dimethyladenosine
  • Cytidine
  • RNA, Transfer
  • N-methyladenosine
  • Adenosine
  • 5-methylcytidine