Elevated 68Ga-DOTATATE Activity in IgG4-Related Lymphadenopathy

Clin Nucl Med. 2018 Oct;43(10):773-776. doi: 10.1097/RLU.0000000000002223.

Abstract

Ga-DOTATATE PET/CT was performed in a 60-year-old man to detect culprit tumor responsible for tumor-induced osteomalacia (TIO). The images revealed multiple foci of abnormal activity in soft tissue lesion, which were not typical of tumor causing TIO in Ga-DOTATATE PET/CT. Considering other neoplastic processes, FDG PET/CT were subsequently performed, which showed all same lesions, although the lesions with highest activity were different between the scans. Pathological examination demonstrated that the patient experienced TIO caused by 1 lesion, but other lesions were due to IgG4-related lymphadenopathy.

Publication types

  • Case Reports

MeSH terms

  • Humans
  • Immunoglobulin G / metabolism*
  • Lymphadenopathy / diagnostic imaging*
  • Lymphadenopathy / immunology*
  • Male
  • Middle Aged
  • Organometallic Compounds*
  • Positron Emission Tomography Computed Tomography*

Substances

  • Immunoglobulin G
  • Organometallic Compounds
  • gallium Ga 68 dotatate