Abstract
A water-soluble near-infrared aminocyanine dye has been developed with a long triplet-state lifetime (τ = 9.16 μs in deaerated ethanol). Thereby, extremely high singlet oxygen quantum yield (ΦΔ = 0.20) and low dark cytotoxicity (IC50 = 715.4 μM) were achieved. The potential of the dye as a PDT photosensitizer was demonstrated.
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / pharmacology*
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Antineoplastic Agents / radiation effects
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Antineoplastic Agents / toxicity
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Apoptosis / drug effects
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Carbocyanines / chemistry
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Cyclic N-Oxides / chemical synthesis
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Cyclic N-Oxides / pharmacology*
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Cyclic N-Oxides / radiation effects
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Cyclic N-Oxides / toxicity
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HeLa Cells
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Humans
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Indoles / chemical synthesis
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Indoles / pharmacology*
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Indoles / radiation effects
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Indoles / toxicity
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Infrared Rays
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Photochemotherapy
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Photosensitizing Agents / chemical synthesis
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Photosensitizing Agents / pharmacology*
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Photosensitizing Agents / radiation effects
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Photosensitizing Agents / toxicity
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Singlet Oxygen
Substances
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Antineoplastic Agents
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Carbocyanines
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Cyclic N-Oxides
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Indoles
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Photosensitizing Agents
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indotricarbocyanine
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Singlet Oxygen